I like all kinds of webcomics, but there are a very few that really stand out for some reason, they may not all be to everyone's taste, but they all have some seriously good qualities. Here's my list:
Gene Catlow http://genecatlow.keenspot.com/
Albert Temple's work here is a good, old-fashioned adventure comic. Modern-day furries and humans with sci-fi and supernatural elements. Something on the more literary side from an author who knows how to tell a story.
DMFA http://www.missmab.com/
Amber Williams has created a very detailed fantasy world filled with all kinds of creatures and beings every bit as involving as something like
Harry Potter, but her real talent is in the way she combines cuteness with violence - a very rare thing when it is done well. The main comic is PG furry humor, but there are some darker and very emotional side stories if you care to go there. All of them are written by someone who is excellent with situational comedy and farce, and knows how to write characters you will fall in love with. As far as I'm concerned, Amber Williams is one of the best writers in comics today, period.
Jack http://www.pholph.com
Probably my favorite. If you like the intensely emotional parts of
TwoKinds, you'll probably like David Hopkins' comic of life, death, and the afterlife. More cinematic than literary. Hopkins is like a film director that takes his cute, very expressive furry characters (and you) to some very dark places in your soul. Don't think that it's some all-dark and angsty comic, though. It's also filled with love, courage and humor. The best part of
Jack is probably the characters and the way they develop and reveal themselves. Also like
TwoKinds, the characters are the kind you will no doubt identify with and love. Seriously, they will make you cry.
The story wanders around a lot and varies in quality, and the artwork is also changed occasionally from story to story. Nice guy that he is, Hopkins gets a lot of friends to do guest art and comic segments. And there is some less-than-fantastic material to wade through, but there is so much excellent content that it's worth it. In the way of warning,
Jack does have a certain amount of profanity, graphic violence and sex, but that's not what it's about. One suggestion, if you decide to check it out, read at least the first four story arcs, up through "Trixi and Tet".